photo H. Cottet 2020

Hervé Cottet


Professor in Analytical Chemistry

Institut des Biomolécules Max Mousseron

Université de Montpellier, UMR CNRS 5247, ENSCM

Place Eugène Bataillon,  Case courrier 1706

34095 Montpellier Cedex 5, France


Phone : (+33) 4 67 14 34 27
Fax : (+33) 4 67 63 10 46

Email :


  Research Interests

Electrokinetic separation techniques
Taylor Dispersion Analysis 

Study of biomolecule interactions (stoichiometry, affinity constants) 
Chemical reactivity of aminoacid N-carboxyanhydrides (NCA)
Characterization of proteins, polyelectrolytes, biopolymers, nanoparticles and colloïds

Electrophoretic mobility modelling
Capillary coatings for protein analysis in CE and CE-MS
Dendrigraft Poly-L-lysine

ORCID iD iconORCiD 0000-0002-6876-175X

Curriculum Vitae




Industrial and academic programs



  Recent papers (2019-2021): complete list here

P135. Generation and characterization of air micro-bubbles in highly hydrophobic capillaries. C. Renard, L. Leclercq, H. Cottet, Electrophoresis, 2021, accepté.

P134. Chemoprevention with a tea from Hawthorn (crataegus oxyacantha) leaves and flowers attenuates colitis in rats by reducing inflammation and oxidative stress. R. de Paula do Nascimento, A. P. da Fonseca Machado, V. Silva Lima, A. M. Tomazini Munhoz Moya, L. M. Reguengo, S. Bogusz Junior, R. Franco Leal, P. Cao-Ngoc; J.-C. Rossi, L. Leclercq, H. Cottet, C. Baú Betim Cazarin, Food Chemistry: X, 2021, accepté.

P133. Biodegradation of metal-based ultra-small nanoparticles: a combined approached using TDA-ICP-MS and CE-ICP-MS. L. Labied, P. Rocchi, T. Doussineau, J. Randon, O. Tillement, H. Cottet, F. Lux, A. Hagège, Analytica Chimica Acta, 2021,1185, 339081.

P132. Unraveling the speciation of β-amyloid peptides during the aggregation process by Taylor dispersion analysis. M. Deleanu, J.-F. Hernandez, L. Cipelletti, J.-P. Biron, E. Rossi, M. Taverna, H. Cottet, J. Chamieh, Anal. Chem., 2021, 93, 6523-6533.

P131. Antigen-adjuvant interactions in vaccines by Taylor dispersion analysis: size characterization and binding parameters. C. Malburet, L. Leclercq, J. F. Cotte, J. Thiebaud, S. Marco, M. C. Nicolaï, H. Cottet, Anal. Chem., 2021, 93, 6508-6515.

P130. Screening for pancreatic lipase natural modulators by capillary electrophoresis hyphenated to spectrophotometric and conductometric dual detection. G. Al Hamoui Dit Banni, R. Nasreddine, S. Fayad, P. Cao-Ngoc, J.-C. Rossi, L. Leclercq, H. Cottet, A. Marchal, R. Nehmé, Analyst, 2021, 146, 1386-1401.

P129. Water-based extraction of Bioactive Principles from Blackcurrant leaves and Chrysanthellum americanum: a comparative study. P. Cao-Ngoc, L. Leclercq, J.-C. Rossi, J. Hertzog, A.-S. Tixier, F. Chemat, R. Nasreddine, G. Al Hamoui Dit Banni, R. Nehmé, P. Schmitt-Kopplin, H. Cottet. Foods, 2020, 9, 1478.

P128. Characterization of ultrahigh molar mass polyelectrolytes by capillary electrophoresis. X. Leclercq, L. Leclercq, A. Guillard, L. Rodriguez, O. Braun, C. Favero, H. Cottet. J. Chromatogr. A, 2020, 461536.

P127. Study of interactions between antigens and polymeric adjuvants in vaccines by frontal analysis continuous capillary electrophoresis. C. Malburet, L. Leclercq, J.-F. Cotte, J. Thiebaud, H. Cottet. Biomacromolecules, 2020, 21, 8, 3364-3373.

P126. Co-solvents in self-emulsifying drug delivery systems (SEDDS) – do they really solve our solubility problems? A. M. Jörgensen, J. D. Friedl, R. Wibel, J. Chamieh, H. Cottet, A. Bernkop-Schnürch, Mol. Pharmaceutics, 2020, 17, 9, 3236–3245.

P125. Capillary Zone Electrophoresis-Top-Down Tandem Mass Spectrometry for in-depth Characterization of Hemoglobin Proteoforms in Clinical and Veterinary Samples. A. Stolz, Y. Hedeland, L. Salzer, J. Römer, R. Heiene, L. Leclercq, H. Cottet, J. Bergquist, C. Neusüß, Anal. Chem., 2020, 92, 15, 10531-10539.

P124. Quantification of adsorption and optimization of separation of proteins in Capillary Electrophoresis. L. Leclercq, C. Renard, M. Martin, H. Cottet. Anal. Chem., 2020, 92, 15, 10743-10750.

P123. Mass transfer efficiency in rare earths extraction using a hollow fiber pertraction device. M. Toure, J. Chamieh, G. Arrachart, S. Pellet-Rostaing, H. Cottet, J. Duhamet, Separation and Purification Technology, 2020, 251, 117330.

P122. Characterization of diblock copolymers by capillary electrophoresis: From electrophoretic mobility distribution to distribution of composition. A. Phimphachanh, J. Chamieh, L. Leclercq, J. Pinaud, S. Harrisson, M. Destarac, P. Lacroix-Desmazes, C. Gérardin, M. In, H. Cottet, Macromolecules, 2020, 53, 334-345.

P121. Optimizing Water-based Extraction of Bioactive Principles of Hawthorn: from Experimental Laboratory Research to Homemade Preparations. P. Cao Ngoc, L. Leclercq, J.-C. Rossi, I. Desvignes, J. Hertzog, A.-S. Tixier, F. Chemat, P. Schmitt-Kopplin, H. Cottet, Molecules, 2019, 24, 4420.

P120. Superhydrophobic capillary coatings: elaboration, characterization and application to electrophoretic separations. C. Renard, L. Leclercq, A. Stocco, H. Cottet, J. Chromatogr. A, 2019, 1603, 361–370.

P119. Size-based characterization of polysaccharides by Taylor Dispersion Analysis with photochemical oxidation or back scattering interferometry detections. L. Leclercq, P. Saetear, A. Rolland-Sabaté, J.-P. Biron, J. Chamieh, L. Cipelletti, D. J. Bornhop, H. Cottet, Macromolecules, 2019, 52, 4421-4431.

P118. Characterization of hydrosoluble fraction and oligomers in poly(vinylidene chloride) latexes by capillary electrophoresis using electrophoretic mobility modeling. A. Ibrahim, H. Cottet, J. Chromatogr. A., 2019, 1598, 223-231.

P117. Supramolecular self-assembly of DNA with a cationic polythiophene – From polyplexes to fibers. M. Leclercq,  J. Rubio-Magnieto, D. Mohammed, S. Gabriele, L. Leclercq, H. Cottet, S. Richeter, S. Clément, M. Surin, ChemNanoMat, 2019, 5, 703-709.

P116. Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis. J. Chamieh, A. Domènech Tarrat, C. Doudou, V. Jannin, F. Demarne, H. Cottet, Int. J. Pharm., 2019, 559, 228-234.

P115. Modulation of the electroosmotic mobility using polyelectrolyte multilayer coatings for protein analysis by capillary electrophoresis. L. Leclercq, M. Morvan, J. Koch, C. Neusuess, H. Cottet, Analytica Chimica Acta, 2019, 1057, 152-161.



    Junior Member of the Institut Universitaire de France (IUF), 2011-2016.

    Awardee 2016 of the French Scholar Series (Peter Wall Institute for Advanced Studies and Frenh Consulate Vancouver)

    Award "Chercheur d'Avenir", Région Languedoc-Roussillon, 2010-2013.

    Award from the French Chemical Society (Analytical Chemistry Division), 2006.

    Lauréat ACI jeunes chercheurs (French National Research Agency), 2004-2008.


Last update: October 7, 2021.

Taylor dispersion analysis, capillary electrophoresis, polyelectrolyte complexes, characterization of polymers, nanoparticles, dendrigraft polymers, dendrimers, analysis of bacteria; analysis of polymers, drug delivery systems. Expertise en électrophorèse capillaire. Consultance en électrophorèse capillaire. Expertise and consultancy in capillary electrophoresis and Taylor dispersion analysis.