photo H. Cottet 0622

Hervé Cottet



Institut des Biomolécules Max Mousseron

Université de Montpellier, UMR CNRS 5247, ENSCM

Place Eugène Bataillon,  Case courrier 1706

34095 Montpellier Cedex 5, France


Phone : (+33) 4 67 14 34 27
Fax : (+33) 4 67 63 10 46

Email :


Participate to the next ITP meeting in Toulouse Sept. 1-4, 2019 !

  Research Interests

Electrokinetic separation techniques (free solution, gel, micellar, isoelectric focusing, isotachophoretic, 2D and frontal modes)
Taylor Dispersion Analysis 

Characterization of polyelectrolytes, biopolymers and colloïds
Study of biomolecule interactions (stoichiometry, affinity constants)
Electrophoretic mobility modelling
Capillary coatings (SMIL)
Characterization and study of bacteria
Dendrigraft Poly-L-lysine


Curriculum Vitae




Industrial and academic programs



  Recent papers (2016-2019): complete list here

P120. Superhydrophobic capillary coatings: elaboration, characterization and application to electrophoretic separations. L. Leclercq, C. Renard, L. Leclercq, A. Stocco, H. Cottet, J. Chromatogr. A, 2019, under revision.

P119. Size-based characterization of polysaccharides by Taylor Dispersion Analysis with photochemical oxidation or back scattering interferometry detections. L. Leclercq, P. Saetear, A. Rolland-Sabaté, J.-P. Biron, J. Chamieh, L. Cipelletti, D. J. Bornhop, H. Cottet, Macromolecules, 2019, accepted.

P118. Characterization of hydrosoluble fraction and oligomers in poly(vinylidene chloride) latexes by capillary electrophoresis using electrophoretic mobility modeling. A. Ibrahim, H. Cottet, J. Chromatogr. A., 20191598, 223-231.

P117. Supramolecular self-assembly of DNA with a cationic polythiophene – From polyplexes to fibers. M. Leclercq,  J. Rubio-Magnieto, D. Mohammed, S. Gabriele, L. Leclercq, H. Cottet, S. Richeter, S. Clément, M. Surin, ChemNanoMat, 20195, 703-709.

P116. Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis. J. Chamieh, A. Domènech Tarrat, C. Doudou, V. Jannin, F. Demarne, H. Cottet, Int. J. Pharm., 2019, 559, 228-234.

P115. Modulation of the electroosmotic mobility using polyelectrolyte multilayer coatings for protein analysis by capillary electrophoresis. L. Leclercq, M. Morvan, J. Koch, C. Neusuess, H. Cottet, Analytica Chimica Acta, 2019, 1057, 152-161.

P114. Mobility shift affinity capillary electrophoresis at high ligand concentrations: application to aluminum chlorohydrate – protein interactions. N. Ouadah, C. Moire, F. Brothier, J.-F. Kuntz, M. Malý, P. Dubský, H. Cottet, ACS Omega, 2018, 3, 12, 17547-17554.

P113. Separation and characterization of highly charged polyelectrolytes by free solution capillary electrophoresis. I. Desvignes, J. Chamieh, H. Cottet, Polymers, 2018, 10, 1331.

P112. Capillary electrophoresis for aluminum ion speciation: optimized separation conditions for complex polycation mixtures. N. Ouadah, C. Moire, F. Brothier, J.-F. Kuntz, O. Deschaume, C. Bartic, H. Cottet, J. Chromatogr. A, 2018, 1552, 79-86.

P111. Characterization of macromolecular structure of synthetic and natural rubber by Taylor dispersion analysis. J. P. Biron, F. Bonfils, L. Cipelletti, H. Cottet, Polymer Testing. 2018, 66, 244-250.

P110. Effect of dendrigraft generation on the interaction between anionic polyelectrolytes and dendrigraft poly-L-lysine. F. Lounis, J. Chamieh, L. Leclercq, P. Gonzalez, J. C. Rossi, H. Cottet, Polymers 2018, 10, 45.

P109. Size characterization of lipid-based self-emulsifying pharmaceutical excipients during lipolysis using Taylor dispersion analysis with fluorescence detection. J. Chamieh, H. Merdassi, J.-C. Rossi, V. Jannin, F. Demarne, H. Cottet, Int. J. Pharm., 2018, 537, 94-101.

P108. Limits in size of Taylor dispersion analysis: representation of the different hydrodynamic regimes and application to the size-characterization of cubosomes. J. Chamieh, L. Leclercq, M. Martin, S. Slaoui, H. Jensen, J. Østergaard, H. Cottet, Anal. Chem. 2017, 89, 13487–1349.

P107. Taylor Dispersion Analysis of polysaccharides using backscattering interferometry. P. Saetear, J. Chamieh, M. Kammer, T. J. Manuel, J. P. Biron, D. J. Bornhop, H. Cottet, Anal. Chem., 2017, 89, 6710–6718.

P106. Interactions between oppositely charged polyelectrolytes by isothermal titration calorimetry: effect of ionic strength and charge density. F. Lounis, J. Chamieh, L. Leclercq, P. Gonzalez, A. Geneste, B. Prelot, H. Cottet, J. Phys. Chem., 2017, 121, 2684–2694.

P105. Analysis and characterization of aluminum chlorohydrate oligocations by capillary electrophoresis. N. Ouadah, C. Moire, J.-F. Kuntz, F. Brothier, H. Cottet, J. Chromatogr. A., 2017, 1492, 144-150.

P104. The effect of molar mass and charge density on the formation of complexes between oppositely charged polyelectrolytes. F. Lounis, J. Chamieh, L. Leclercq, P. Gonzalez, H. Cottet, Polymers, 2017, 9, 50.

P103. Determination of the Distributions of the Degrees of Acetylation of Chitosan. J. Thevarajah, M. Van Leeuwen, H. Cottet, P. Castignolles, M. Gaborieau, International Journal of Biological Macromolecules, 2017, 95, 40-48.

P102. On the ionic strength dependence of the electrophoretic mobility: from 2D to 3D slope-plots. H. Cottet, H. Wu, S. A. Allison, Electrophoresis, 2017, 38, 624-632.

P101. Study of the interactions between oppositely and variously charged polyelectrolytes by frontal analysis continuous capillary electrophoresis. F. M. Lounis, J. Chamieh, L. Leclercq, P. Gonzalez, H. Cottet, Soft Matter, 2016, 12, 9728 - 9737.

P100. Advanced  portrayal  of  SMIL  coating  by  allying  CZE  performance  with  in-capillary topographic and charge-related surface characterization. L. G. Stock, M. Leitner, L. Traxler, K. Bonazza, L. Leclercq, H. Cottet, G. Friedbacher, A. Ebner, H. Stutz, Analytica Chimica Acta, 2016, 930, 39-48.

P99. What is the contribution of counter-ions in the absolute molar mass of polyelectrolytes determined by SEC/MALLS ? P. Gonzalez, L. Leclercq, H. Cottet, Macromol. Chem. Phys., 2016, 217, 2654–2659.

P98. Hydrodynamic size characterization of a self-emulsifying lipid pharmaceutical excipient by Taylor dispersion analysis with fluorescent detection. J. Chamieh, V. Jannin, F. Demarne, H. Cottet, Int. J. Pharm., 2016, 513, 262-269.

P97. Mapping Molecular Adhesion Sites inside SMIL coated Capillaries using Atomic Force Microscopy Recognition Imaging. M. Leitner, L. G. Stock, L. Traxler, L. Leclercq, K. Bonazza, G. Friedbacher, H. Cottet, H. E. Stutz, A. Ebner, Analytica Chimica Acta, 2016, 930, 39-48.

P96. Prediction of polyelectrolyte complex stoichiometry for highly hydrophilic polyelectrolytes. F. Lounis, J. Chamieh, P. Gonzalez, H. Cottet, L. Leclercq, Macromolecules, 2016, 49, 3881–3888.

P95. A new robust estimator of polydispersity from dynamic light scattering data. V. Roger, H. Cottet, L. Cipelletti, Anal. Chem., 2016, 88, 2630-2636.

P94. Quantifying the heterogeneity of chemical structures in complex charged polymers through the dispersity of their distributions of electrophoretic mobilities or of compositions. J. J. Thevarajah, A. T. Sutton, A. R. Maniego, E. G. Whitty, S. Harrison, H. Cottet, P. Castignolles, M. Gaborieau, Anal. Chem., 2016, 88, 1674-1681.

P93. Influence of the ionic strength of acidic background electrolytes on the separation of proteins by capillary electrophoresis. S. Bekri, L. Leclercq, H. Cottet, J. Chromatogr. A, 2016, 1432, 145-151.



  Awardee 2016 of the French Scholar Series (Peter Wall Institute for Advanced Studies and Frenh Consulate Vancouver)

    Junior Member of the Institut Universitaire de France (IUF), 2011-2016.

    Award "Chercheur d'Avenir", Région Languedoc-Roussillon, 2010-2013.

    Award from the French Chemical Society (Analytical Chemistry Division), 2006.

    Lauréat ACI jeunes chercheurs (French National Research Agency), 2004-2008.


1st European Workshop on Taylor Dispersion Analysis
(held on monday june 2, 2014 in Montpellier)

2nd European Workshop on Taylor Dispersion Analysis
(held on monday june 6, 2016 in Copenhagen)  here 

Last update: June 11, 2019.

Taylor dispersion analysis, capillary electrophoresis, polyelectrolyte complexes, characterization of polymers, nanoparticles, dendrigraft polymers, dendrimers, analysis of bacteria; analysis of polymers, drug delivery systems. Expertise en électrophorèse capillaire. Consultance en électrophorèse capillaire. Expertise and consultancy in capillary electrophoresis and Taylor dispersion analysis.